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almost exclusively by events in the tubular epithelium rather than the vascular endothelium; second, the cortical interstitium, which is the medium faced by the basolateral membranes of the tubular epithelia, has an osmolality and concentration of small solutes close to those in plasma. The interstitial composition changes when plasma composition changes. In the medulla, where both blood flow and transport events are quantitatively lower, things are far more complicated. Only some regions of the vasculature are fenestrated, so that (1) the overall transport depends on both the properties of the vascular endothelium and tubular epithelium, and (2) the medullary interstitium is most definitely not plasma-like in its composition. We will address the importance of these medullary properties later. For now, we direct our attention in the rest of this chapter to epithelial transport. Crossing the tubular epithelium can be performed in a single step or two steps. The paracellular route (single step) is when the substance goes around the cells (ie, through the matrix of the tight junctions that link each epithelial cell to its neighbor). More often, however, a substance goes through the cells, a two-step process: across the apical membrane facing the tubular lumen and across the basolateral membrane facing the interstitium. This is called the transcellular route. These structures and pathways are depicted in Figures 4 1A and B. An array of mechanisms exists by which substances cross the various barriers. The general classes of mechanisms are no different from those used elsewhere in the body to transport substances across cell membranes. We can view these mechanisms as a physiological tool box. Renal cells use whichever set of tools is most suitable for the task. The general classes of mechanisms for traversing the barriers are depicted in Figure 4 2. replace text in pdf using itextsharp in c# How to replace text in pdf file - MSDN - Microsoft
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